The unique properties of the ELA® cell give it advantages over many other regenerative cells, including:
Availability:
Through Parcell's proprietary isolation protocol, ELA cells can be harvested in large concentrations allowing for therapeutic doses of cells without the need for culture expansion.
Targeted Doses:
ELA cells are cryopreserved and stored in several concentrations to meet the therapeutic need for structural tissue at a site of injury. Many cellular therapies are based on the harvesting and expansion of a patient's own cells. This can be a painful procedure with longer term discomfort at the site of extraction. ELA cells give surgeons access to structural tissue for transplant at a site of injury without the need to extract tissue from elsewhere on the patient.
Compatibility:
Some cellular therapies require the matching of the donor to the recipient to prevent rejection of the tissue. In contrast, ELA cells are immune privileged and can be implanted without the risk of rejection by the recipient's immune system. ELA cells do not elicit a negative immune response when transplanted, as they lack the antigens that would normally trigger an immune reaction. Most adult cells display Human Leukocyte Antigens (HLA) on their surface like banners identifying each cell as either a host, foreign or infected cell. Missing these cell-surface antigens, ELA cells escape detection by the cellular sentinels of the immune system, avoiding the additional tissue damage that often occurs during an immune response.
Immune Homeostasis
The implantation of ELA cells allows the tightly regulated local tissue repair network to maintain cellular balance, thus preventing the under or over reaction of the local immune response associated with tissue repair.